Dysregulation ofPLDN(pallidin) is a mechanism for platelet dense granule deficiency inRUNX1haplodeficiency
نویسندگان
چکیده
منابع مشابه
Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.
INTRODUCTION Dense granule (DG) deficiency (DGD) is a feature of some platelet function disorders (PFD) with a prevalence similar to von Willebrand disease. Most laboratories assess for DGD using whole mount platelet preparations and electron microscopy (EM). We evaluated our experiences with this test and associations between DGD and bleeding. METHODS Dense granule EM records for 2006-2017 w...
متن کاملPKD is for dense granule secretion.
http://bloodjournal.hematologylibrary.org/content/118/2/220.full.html Updated information and services can be found at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering r...
متن کاملQuantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency.
An antigen-capture sandwich enzyme-linked immunosorbent assay (ELISA) was developed for a novel protein granulophysin, a constituent of the platelet dense granule (DG) membrane and used to characterize patients with dense granule storage pool deficiency (delta-SPD). The assay uses two monoclonal antibodies against the protein, one of which is conjugated to peroxidase. Purified DGs, an enriched ...
متن کاملThe actin cytoskeleton differentially regulates platelet -granule and dense-granule secretion
http://bloodjournal.hematologylibrary.org/content/105/10/3879.full.html Updated information and services can be found at: (1930 articles) Signal Transduction (2497 articles) Hemostasis, Thrombosis, and Vascular Biology (143 articles) Cytoskeleton Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#r...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY The actin cytoskeleton differentially regulates platelet -granule and dense-granule secretion
Stimulation of platelets with strong agonists results in centralization of cytoplasmic organelles and secretion of granules. These observations have led to the supposition that cytoskeletal contraction facilitates granule release by promoting the interaction of granules with one another and with membranes of the open canalicular system. Yet, the influence of the actin cytoskeleton in controllin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2017
ISSN: 1538-7933
DOI: 10.1111/jth.13619